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Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

Ruizheng Sun1,2,3, Ranran Wang4, Siyuan Chang1,2,3

  • 1Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Pharmacology
|January 11, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial in non-small cell lung cancer (NSCLC) drug resistance. Understanding lncRNAs offers new strategies to overcome treatment challenges in NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Lung cancer is a leading cause of cancer mortality worldwide.
  • Non-small cell lung cancer (NSCLC) accounts for 83% of lung cancer cases.
  • Drug resistance significantly contributes to the poor prognosis of NSCLC patients.

Purpose of the Study:

  • To review the critical role of long non-coding RNAs (lncRNAs) in the development of drug resistance in NSCLC.
  • To highlight lncRNAs as key regulators in NSCLC chemoresistance.

Main Methods:

  • Literature review of recent studies on lncRNAs and drug resistance in NSCLC.
  • Analysis of the mechanisms by which lncRNAs influence drug sensitivity in NSCLC cells.

Main Results:

  • lncRNAs, often termed "dark matters" of the genome, play a significant role in mediating drug resistance in NSCLC.
  • Specific lncRNAs have been identified that can either promote or inhibit the efficacy of various chemotherapeutic agents.

Conclusions:

  • lncRNAs represent a promising therapeutic target for overcoming drug resistance in NSCLC.
  • Further research into lncRNA functions could lead to novel treatment strategies for NSCLC patients facing drug resistance.
Keywords:
cisplatindrug resistanceepidermal growth factor receptor tyrosine kinase inhibitorsimmune checkpoint inhibitorslong non-coding RNAsnon-small cell lung cancertaxanes

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