Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hydrogen Bonds01:04

Hydrogen Bonds

12.8K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
12.8K
Hydrogen Bonds00:26

Hydrogen Bonds

129.4K
Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
129.4K
Protein Folding01:22

Protein Folding

125.6K
Overview
125.6K
Protein Folding01:25

Protein Folding

10.8K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
10.8K
Hybridization of Atomic Orbitals I03:24

Hybridization of Atomic Orbitals I

64.7K
The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...
64.7K
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

47.2K
sp3d and sp3d 2 Hybridization
47.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>De novo</i> grafted coiled-coil peptides as p53/<i>h</i>DM2 inhibitors.

RSC chemical biology·2026
Same author

Discovery of SHANK1-PDZ Peptide-Fragment Inhibitors Using a Dynamic Ligation Screening Strategy.

Biochemistry·2026
Same author

Covalent Peptide-Based N-Myc/Aurora-A Inhibitors Bearing Sulfonyl Fluoride Warheads.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same author

Bora bridges Aurora-A activation and substrate recognition of PLK1.

EMBO reports·2026
Same author

Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion.

Nature communications·2025
Same author

Pyrrolidine-based hybrid compounds: design, synthesis, in vitro and in vivo pharmacological properties and molecular docking studies.

Future medicinal chemistry·2025
Same journal

Exploring Antimicrobial Activities of Fixed Oil From Sanguisorba minor Seeds by In Vitro and In Silico Analysis.

ChemistryOpen·2026
Same journal

Chemical and Technological Aspects of Magnetic Particles for Cancer Liquid Biopsy Applications.

ChemistryOpen·2026
Same journal

Monthly Energy, Exergy, Environmental, and Economic Performance and Green Hydrogen Production Analysis of a Flat-Plate Solar Collector-Driven Organic Rankine Cycle System Under Variable Mass Flow and Irradiance.

ChemistryOpen·2026
Same journal

The Versatile Structural World of Methanedi- and Trisulfonic Acid and Their Salts.

ChemistryOpen·2026
Same journal

The Role of Conformational Preorganization in the Reactivity of cis-1,2-Dimesylate-bis(benzyloxy)cyclooctane: An Activation Strain Perspective.

ChemistryOpen·2026
Same journal

Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism.

ChemistryOpen·2026
See all related articles

Related Experiment Video

Updated: Dec 31, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.6K

A pH-Switchable Triple Hydrogen-Bonding Motif.

Heather M Coubrough1, Barbora Balonova2, Christopher M Pask1

  • 1School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, U.K.

Chemistryopen
|January 11, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a novel stimuli-responsive hydrogen bonding motif that can switch its molecular recognition preference. This advancement enables tunable molecular interactions for advanced material design.

Keywords:
hydrogen bondingmolecular recognitionpH-responsive systemsself-sorting networkssupramolecular chemistry

More Related Videos

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.5K
Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
11:37

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

18.9K

Related Experiment Videos

Last Updated: Dec 31, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.6K
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.5K
Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
11:37

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

18.9K

Area of Science:

  • Supramolecular Chemistry
  • Chemical Biology

Background:

  • Hydrogen bonding motifs are fundamental in molecular recognition and self-assembly.
  • Stimuli-responsive systems offer dynamic control over chemical and biological processes.

Purpose of the Study:

  • To investigate a novel linear hydrogen bonding motif with in-situ protonation and deprotonation capabilities.
  • To explore the switching behavior of this motif's molecular recognition in response to stimuli.

Main Methods:

  • Utilized proton nuclear magnetic resonance (¹H NMR) spectroscopy.
  • Examined interactions between the responsive motif and complementary molecular partners.
  • Analyzed recognition preferences in mixed systems.

Main Results:

  • Demonstrated the stimuli-responsive nature of the hydrogen bonding motif.
  • Confirmed the ability of the motif to undergo in-situ protonation and deprotonation.
  • Showcased the switching of recognition preference between two distinct states in a mixture.

Conclusions:

  • The developed hydrogen bonding motif exhibits tunable recognition properties.
  • This system provides a platform for designing dynamic and switchable molecular interactions.
  • Potential applications in smart materials, sensors, and drug delivery systems.