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Updated: Dec 31, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Published on: July 14, 2015
A pH-Switchable Triple Hydrogen-Bonding Motif
Heather M Coubrough1, Barbora Balonova2, Christopher M Pask1
1School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, U.K.
Abstract:
A stimuli responsive linear hydrogen bonding motif, capable of in situ protonation and deprotonation, has been investigated. The interactions of the responsive hydrogen bonding motif with complementary partners were examined through a series of 1H NMR experiments, revealing that the recognition preference of the responsive hydrogen bonding motif in a mixture can be switched between two states.
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