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A counterfeit multivitamin product inducing severe bleeding disorders in humans
Lina Peña-Acevedo1, Andres F Zuluaga1, Alexander Aristizabal-Solis2
1CIEMTO [drug and poison research and information center] at Integrated Laboratory of Specialized Medicine (LIME), Facultad de Medicina-IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.
A falsified dietary supplement contaminated with warfarin caused bleeding and coagulation issues in 36 individuals in Colombia. Prompt detection by poison control centers is crucial for public health safety.
Area of Science:
- Toxicology
- Public Health
- Pharmacovigilance
Background:
- 36 individuals in Antioquia, Colombia, reported bleeding and coagulation abnormalities.
- Symptoms arose after consuming a falsified dietary supplement over six months.
Purpose of the Study:
- To investigate the cause of adverse health effects linked to a specific dietary supplement.
- To highlight the role of poison control centers in identifying public health threats.
Main Methods:
- Case series reporting clinical manifestations and management.
- Investigation by the Colombian Food and Drug Administration (INVIMA).
Main Results:
- Patients required hospitalization and treatment with blood products and vitamin K.
- Warfarin was identified as the primary contaminant in the supplement.
- Full recovery was observed within one week of management.
Conclusions:
- Falsified supplements pose significant public health risks.
- Poison control centers are vital for early detection of product-related hazards.
- Regulatory action, including product withdrawal, is essential.
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