The plateau at V˙ O_2max is associated with anaerobic alleles

This study tests the hypothesis that individuals who achieve a plateau at V˙ O_2max (V˙ O_2plat) are more likely to possess alleles, associated with anaerobic capacity, than those who do not.

A literature survey, physiological testing and genetic analysis was used to determine any association between the aerobic and anaerobic polymorphisms of 40 genes and V˙ O_2plat.

34, healthy, Caucasian volunteers, completed an exercise test to determine V˙ O_2max, and  V˙ O_2plat. 28 of the volunteers agreed to DNA testing and 26 were successfully genotyped. A literature search was used to determine whether the 40 polymorphisms analysed were associated with aerobic, or anaerobic exercise performance.

The literature survey enabled classification of the 40 target alleles as aerobic [11], anaerobic [24], or having no apparent association (NAA) [5] with exercise performance. It also found no previous studies linking a genetic component with the ability to achieve V˙ O_2plat. Independent t-tests showed a significant difference (p < 0.001) in the ability to achieve V˙ O_2plat, but no other measured physiological variable was significantly different. Pearson's χ² testing demonstrated a highly significant association (p = 0.008) between anaerobic allele frequency and V˙ O_2plat, but not with V˙ O_2max. There was no association between aerobic alleles and V˙ O_2plat, or V˙ O_2max. Finally there were no significant differences in the allelic frequencies, observed in this study and those expected of Northern and Western European Caucasians.

These results support the hypothesis that the ability to achieve V˙ O_2plat is associated with alleles linked to anaerobic exercise capacity.