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The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and

Gang Li1, Bingxu Meng1, Baokun Yuan1

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, PR China.

European Journal of Medicinal Chemistry
|January 12, 2020
PubMed

Keywords:
DPP-IVDruggabilityGPR119HBK001Xanthine compounds

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