Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vulvitis circumscripta plasmacellularis treated successfully with interferon alpha.

S Morioka1, S Nakajima, H Yaguchi

  • 1Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.

Journal of the American Academy of Dermatology
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atopic dermatitis: studies of skin permeability and effectiveness of topical PUVA treatment.

Pediatric dermatology·1992
Same author

Stimulation of keratinocyte migration by growth factors.

The Journal of dermatology·1992
Same author

A wound healing model using healing-impaired diabetic mice.

The Journal of dermatology·1992
Same author

The response to drug therapy in unstable angina on the basis of coronary angiography findings.

Japanese circulation journal·1992
Same author

[The pathogenic role of Chlamydia trachomatis in otitis media with effusion].

Nihon Jibiinkoka Gakkai kaiho·1992
Same author

[Prospective randomized trials comparing hyperfractionated radiotherapy with conventional radiotherapy in stage III non-small cell lung cancer].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same journal

Comparative Alopecia Outcomes After Copper and Hormonal Intrauterine Device Placement: A TriNetX Database Retrospective Cohort Study.

Journal of the American Academy of Dermatology·2026
Same journal

Uncovering a Dual Th17/Type 2 Transcriptomic Endotype in Psoriasis.

Journal of the American Academy of Dermatology·2026
Same journal

Dermatologic conditions associated with HIV among US adults across different racial and ethnic groups: A retrospective cohort study using TriNetX.

Journal of the American Academy of Dermatology·2026
Same journal

Ethical Considerations in Same-Day Surgical Treatment of a High-Risk, Poorly Differentiated Squamous Cell Carcinoma.

Journal of the American Academy of Dermatology·2026
Same journal

The Ethics of the Handshake in Dermatology.

Journal of the American Academy of Dermatology·2026
Same journal

Dermatology images: Hidradenitis suppurativa.

Journal of the American Academy of Dermatology·2026
See all related articles

Intralesional interferon alpha injections effectively treated vulvitis circumscripta plasmacellularis, a condition resistant to conventional therapies. This suggests herpes simplex virus may play a role in its development.

Area of Science:

  • Dermatology
  • Immunology
  • Virology

Background:

  • Vulvitis circumscripta plasmacellularis is a rare inflammatory condition affecting the vulva.
  • Conventional treatments including corticosteroids, cryotherapy, and surgery often yield poor results and disease recurrence.

Observation:

  • A 74-year-old woman presented with persistent vulvitis circumscripta plasmacellularis unresponsive to long-term conventional therapies.
  • Herpes simplex virus antigen was detected in the lesions via direct immunofluorescence staining prior to treatment.

Findings:

  • Intralesional interferon alpha injections led to significant clinical improvement of the vulvar lesions.
  • Histological examination confirmed a decrease in plasma cell infiltrate post-treatment.
  • The herpes simplex virus antigen disappeared following interferon alpha therapy.

Related Experiment Videos

Implications:

  • Local interferon alpha injections represent a promising therapeutic option for refractory vulvitis circumscripta plasmacellularis.
  • The findings suggest a potential role for herpes simplex virus infection in the pathogenesis of this condition.