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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
983
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity
1Nutrition Research Institute, Department of Nutrition, University of North Carolina, Kannapolis, North Carolina 28081, USA;
Annual Review of Food Science and Technology
|January 14, 2020
Summary
Precision nutrition stratifies people into subgroups based on metabolic variations for tailored dietary advice. This approach, focusing on genetics and other factors, aims for better recommendations than one-size-fits-all diets.
Area of Science:
- Nutritional Science
- Genomics
- Metabolomics
Background:
- Individual dietary needs and responses vary due to genetics, epigenetics, microbiome, lifestyle, and environment.
- Metabolic heterogeneity is a key factor influencing nutrient and bioactive molecule interactions.
- Current dietary recommendations often lack personalization, leading to suboptimal health outcomes.
Purpose of the Study:
- To define precision nutrition as a field stratifying populations by metabolic variation.
- To explore genetically related sources of metabolic heterogeneity.
- To identify challenges and commercial applications in precision nutrition.
Main Methods:
- Review of scientific literature focusing on genetic influences on metabolic heterogeneity.
- Analysis of biomarkers for stratifying population subgroups.
- Discussion of interactions between various sources of metabolic variation.
Main Results:
- Precision nutrition stratifies individuals into subgroups for targeted dietary recommendations.
- Genetics plays a significant role in metabolic heterogeneity.
- Understanding complex interactions between various factors is crucial.
Conclusions:
- Precision nutrition offers a framework for more effective dietary recommendations by subgrouping, not individualizing.
- Further research is needed to understand the interplay of genetic and non-genetic factors.
- Commercial applications of precision nutrition are emerging.
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