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Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property.
Yong-Jin Wu1, Yan-Nan Song2, Xiao-Rui Geng1
1ENT Hospital of Shenzhen University School of Medicine, Longgang ENT Hospital, Shenzhen, China.
International Journal of Biological Sciences
|January 14, 2020
Summary
Soluble CD83 (sCD83) plays a crucial role in immune regulation for allergic rhinitis (AR). Lower sCD83 levels in AR patients correlate with increased T helper-2 cells, and sCD83 administration effectively alleviates experimental AR.
Area of Science:
- Immunology
- Allergy Research
Background:
- Immune dysregulation is implicated in allergic rhinitis (AR) pathogenesis.
- Soluble CD83 (sCD83) exhibits immune regulatory properties.
- The specific role of sCD83 in AR requires further elucidation.
Purpose of the Study:
- To investigate the role of sCD83 in alleviating experimental AR.
- To determine the relationship between sCD83 levels and immune cell activity in AR patients.
Main Methods:
- Serum sCD83 levels were measured in AR patients and healthy controls using ELISA.
- A murine model of AR was employed to assess sCD83 treatment efficacy.
- T helper-2 (Th2) cell frequency and Bcl2L12 expression were analyzed.
Main Results:
- AR patients exhibited lower serum sCD83 levels compared to controls.
- Reduced sCD83 levels correlated negatively with Th2 cell frequency.
- sCD83 administration suppressed experimental AR by enhancing Th2 cell apoptosis via Bcl2L12 downregulation.
Conclusions:
- sCD83 contributes to immune homeostasis by modulating CD4+ T cell activity.
- sCD83 demonstrates potential as a therapeutic agent for AR and other allergic conditions.
