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Tuberculosis drug resistance in Canada: 2018
Marie LaFreniere1, Demy Dam1,2,3, Lori Strudwick4
1Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Summary
Drug-resistant tuberculosis (TB) remains a global concern. In Canada, TB drug resistance in 2018 was low, with stable geographic and demographic patterns, remaining below global averages.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- Drug-resistant tuberculosis (TB) is a significant global public health challenge.
- Nationwide surveillance in Canada monitors drug resistance trends to support TB elimination goals.
Purpose of the Study:
- To analyze TB drug resistance trends in Canada from 2008 to 2018, focusing on 2018.
- To examine geographic and demographic patterns of TB drug resistance.
Main Methods:
- Utilized data from the Canadian Tuberculosis Laboratory Surveillance System (CTBLSS) and Canadian Tuberculosis Reporting System (CTBRS).
- Conducted descriptive statistical analysis by resistance profile, geography, age, sex, and country of birth.
Main Results:
- In 2018, 10.1% of TB isolates showed resistance to first-line drugs, an increase from 2017.
- Multidrug-resistant TB (MDR-TB) was found in 21 isolates, and extensively drug-resistant TB (XDR-TB) in one.
- Drug resistance was present across most provinces, with variations by age, sex, and country of birth; foreign-born cases had higher resistance rates.
Conclusions:
- TB drug resistance in Canada in 2018 was low and below global averages.
- Geographic and demographic patterns of drug resistance remained stable.
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