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Updated: Dec 31, 2025
Author Spotlight: Marmoset Research - Scope and Challenges
Published on: June 9, 2023
A pilot study to establish human T-cell leukemia virus type 1 (HTLV-1) carrier model using common marmoset
Lisa Hirose1, Takafumi Hiramoto1, Yamin Tian1
1Project Division of ALA Advanced Medical Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Background:
For the diagnosis and treatment of adult T-cell leukemia/lymphoma (ATLL) caused by human T-lymphotropic virus type 1 (HTLV-1) are required therapeutic modalities urgently. Non-human primate models for ATLL would provide a valuable information for clinical studies. We did a pilot study to establish an ATLL non-human primate model using common marmosets (Callithrix jacchus).
Methods:
We inoculated HTLV-1-producing MT-2 cells into 9-month-old marmosets, either intraperitoneally or intravenously. We next administrated MT-2 cells into 13-month-old marmosets under cyclosporine A (CsA) treatment to promote infection. HTLV-1 infection was determined by measuring HTLV-1 antibody titer in the common marmosets.
Results:
The HTLV-1 antibody titer increased in the intraperitoneally inoculated marmoset with or without CsA treatment, and it kept over five 5 years though proviral copy number (proviral load, PVL) remained low throughout the study.
Conclusion:
We obtained HTLV-1 asymptomatic carriers of common marmosets by inoculating MT-2 cells.
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