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Updated: Dec 31, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Development of the Circadian Core Machinery in Mammals
Yasuhiro Umemura1, Kazuhiro Yagita1
1Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan.
Abstract:
The emergence of circadian molecular oscillation is observed as a gradual process during the development in mammals. Pluripotent stem cell differentiation cultures recapitulate this process, whereas reprogramming into an undifferentiated state reverses it. These findings indicate that the circadian clock is tightly coupled to the state of cellular differentiation. The state of the circadian core machinery in nonrhythmic cells may be different from that in rhythmic cells. In this review, we describe the circadian rhythm development during ontogeny in mammals and focus on the molecular mechanisms that suppress circadian molecular oscillations during early development and in pluripotent stem cells. We also discuss the biological implications of repressing cellular circadian oscillation in nonrhythmic cells.
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