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Blood glucose concentration control for type 1 diabetic patients: a multiple-model strategy
Yazdan Batmani1, Shadi Khodakaramzadeh2
1Department of Electrical Engineering, University of Kurdistan, Sanandaj, Iran. y.batmani@uok.ac.ir.
IET Systems Biology
|January 14, 2020
Summary
A new multiple-model strategy for closed-loop insulin delivery in type 1 diabetes effectively manages blood glucose levels. This approach limits hyperglycemia and prevents severe hypoglycemia in simulations.
Area of Science:
- Biomedical Engineering
- Control Systems Engineering
- Endocrinology
Background:
- Type 1 diabetes management requires precise glucose-insulin regulation.
- Existing closed-loop systems face challenges with physiological non-linearities and delivery delays.
- Advanced control strategies are needed for improved glycemic control.
Purpose of the Study:
- To evaluate a multiple-model strategy as an alternative closed-loop method for subcutaneous insulin delivery.
- To address the non-linear dynamics of the glucose-insulin system.
- To develop a robust control system that accounts for physiological delays.
Main Methods:
- Modelling the glucose-insulin system around five operating points using the UVA/Padova metabolic simulator.
- Obtaining five transfer functions and tuning five PID controllers for each operating point.
- Implementing a glucose-dependent setpoint to manage delays in glucose measurement and insulin administration.
Main Results:
- The multiple-model strategy demonstrated effective closed-loop glucose-insulin regulation.
- Simulations showed limited hyperglycemia in the type 1 diabetes cohort.
- No instances of severe hypoglycemia were observed with the proposed strategy.
Conclusions:
- The multiple-model strategy offers a promising alternative for closed-loop insulin delivery in type 1 diabetes.
- This approach enhances glycemic control by addressing system non-linearities and delays.
- The findings suggest potential for improved patient outcomes in diabetes management.
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