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Related Concept Videos

Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

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For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
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Enzymes02:34

Enzymes

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Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
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Enzymes and Activation Energy01:13

Enzymes and Activation Energy

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The activation energy (or free energy of activation), abbreviated as Ea, is the small amount of energy input necessary for all chemical reactions to occur. During chemical reactions, certain chemical bonds break, and new ones form. For example, when a glucose molecule breaks down, bonds between the molecule's carbon atoms break. Since these are energy-storing bonds, they release energy when broken. However, the molecule must be somewhat contorted to get into a state that allows the bonds to...
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Enzyme-linked Receptors01:00

Enzyme-linked Receptors

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Enzyme Kinetics01:19

Enzyme Kinetics

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Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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Updated: Dec 31, 2025

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation
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Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

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Magneto-controlled enzyme reactions.

Paolo Bollella1, Evgeny Katz1

  • 1Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, United States.

Methods in Enzymology
|January 15, 2020
PubMed
Summary
This summary is machine-generated.

Magnetic nanoparticles enable precise control over enzyme reactions, activating or inhibiting them via magnetic fields. This technology offers new possibilities for bioelectronic systems and biocatalysis.

Keywords:
Biocatalytic reactionBioelectrocatalysisElectrodeEnzymeMagnetic particlesMagneto-controlled reactionsMagneto-switchable processesMagnetohydrodynamic effectSubstrate channelingSubstrate diffusion

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Area of Science:

  • Biocatalysis
  • Bioelectrochemistry
  • Nanotechnology

Background:

  • Enzyme reactions are crucial in biological processes.
  • Controlling enzyme activity with external stimuli is desirable for applications.
  • Magnetic nanoparticles offer unique properties for manipulation.

Purpose of the Study:

  • To explore various magneto-controlled biocatalytic enzyme reactions.
  • To demonstrate the use of magnetic nanoparticles in controlling enzyme activity.
  • To highlight applications in bioelectronic systems.

Main Methods:

  • Functionalizing magnetic nanoparticles with enzymes, cofactors, or mediators.
  • Using magnetic fields for particle translocation, deposition, and removal.
  • Investigating aggregation/disaggregation effects on biocatalytic cascades.
  • Applying magnetohydrodynamics to enhance bioelectrocatalytic processes.

Main Results:

  • Magneto-induced particle deposition activated bioelectrocatalytic reactions.
  • Magneto-induced particle removal inhibited electrochemical reactions.
  • Enzyme-modified nanoparticle aggregation/disaggregation reversibly altered biocatalytic cascade mechanisms.
  • Magnetohydrodynamic activation enhanced biofuel cell performance.

Conclusions:

  • Magnetic nanoparticles provide a versatile platform for magneto-controlled biocatalysis.
  • This approach enables reversible control over enzyme reaction rates and mechanisms.
  • Magneto-controlled biocatalysis has significant potential in bioelectronic devices and biosensors.