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Related Experiment Video

Updated: Dec 31, 2025

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart
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Conventional and Emerging Markers in Stem Cell Isolation and Characterization.

Chavali Kavyasudha1, Joel P Joseph1, Rama Jayaraj2

  • 1Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, India.

Advances in Experimental Medicine and Biology
|January 15, 2020
PubMed
Summary

This review discusses conventional and emerging stem cell markers for identifying and isolating stem cells. Understanding these markers is crucial for advancing cell-based therapies in regenerative medicine.

Keywords:
Conventional markersEmerging markersEpidermal SCs markersMSC markersNSC markersStem cell markers

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Biomarker Discovery

Background:

  • Stem cells offer significant therapeutic potential for regenerative medicine, with several products in clinical trials.
  • Challenges in stem cell isolation and characterization arise from the lack of standardized markers for novel sources.
  • Established biomarkers aid stem cell identification, but emerging markers offer additional or independent characterization methods.

Purpose of the Study:

  • To review conventionally used and emerging markers for stem cell identification and isolation.
  • To discuss the application of these markers across various stem cell niches and germ layer origins.
  • To highlight advancements in stem cell characterization for therapeutic development.

Main Methods:

  • Literature review of scientific publications on stem cell markers.
  • Analysis of established and novel biomarkers for stem cell identification.
  • Synthesis of information on stem cell characterization techniques.

Main Results:

  • Conventional markers are well-established for certain stem cell types.
  • Emerging markers provide new avenues for identifying and characterizing stem cells, potentially independent of traditional markers.
  • A comprehensive understanding of diverse markers is essential for diverse stem cell applications.

Conclusions:

  • Accurate identification and characterization of stem cells are critical for successful cell-based therapies.
  • Emerging markers enhance the ability to isolate and define stem cells from various sources.
  • Further research into novel biomarkers will accelerate the development of regenerative medicine.