Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer Vaccines01:30

Cancer Vaccines

884
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
884
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

3.7K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.7K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safe Meat, Smart Science: Biotechnology's Role in Antibiotic Residue Removal.

Antibiotics (Basel, Switzerland)·2025
Same author

Study on the protective effects and mechanisms of eleutherococcus senticosus on korsakoff syndrome.

Frontiers in neuroscience·2025
Same author

Diallyl Trisulfide and Cardiovascular Health: Evidence and Potential Molecular Mechanisms.

International journal of molecular sciences·2024
Same author

Methylene blue in anticancer photodynamic therapy: systematic review of preclinical studies.

Frontiers in pharmacology·2023
Same author

Cooling down with Entresto. Can sacubitril/valsartan combination enhance browning more than coldness?

Diabetology & metabolic syndrome·2022
Same author

Development and Validation of four Nitrosamine Impurities Determination Method in Medicines of Valsartan, Losartan, and Irbesartan with HPLC-MS/MS (APCI).

Iranian journal of pharmaceutical research : IJPR·2021

Related Experiment Video

Updated: Dec 31, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.8K

Peptide-Based Therapeutics for Oncology.

Elizaveta Fisher1,2, Kirill Pavlenko3, Alexander Vlasov4

  • 1Sechenov First State Medical University, 8-2, Trubetskaya str, 119991, Moscow, Russia. elizaveta.fisher@mail.ru.

Pharmaceutical Medicine
|January 15, 2020
PubMed
Summary

Peptide-based drugs offer a safer, more effective alternative to traditional cancer treatments like chemotherapy. Ongoing research explores their potential and addresses concerns about oncogenic properties.

More Related Videos

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.6K
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.3K

Related Experiment Videos

Last Updated: Dec 31, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.8K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.6K
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.3K

Area of Science:

  • Drug Development
  • Oncology
  • Biochemistry

Background:

  • Peptide-based drugs, synthetic analogues of endogenous peptides, are a significant area in drug development.
  • Antitumor peptides, classified as inhibitory, necrosis-inducing, or pro-apoptotic, show promise as cancer therapeutics.
  • Peptides offer advantages over chemotherapy and surgery, including better safety, tolerability, and fewer adverse effects.

Purpose of the Study:

  • To highlight the advantages of peptide-based drugs in cancer therapy.
  • To discuss the classification and mechanisms of anticancer peptides.
  • To address the challenges and ongoing research in peptide-based cancer therapeutics.

Main Methods:

  • Review of existing literature on peptide-based drug development.
  • Classification of anticancer peptides based on their mechanisms of action.
  • Analysis of the benefits and challenges of peptide therapeutics in preclinical and clinical studies.

Main Results:

  • Short peptides exhibit superior stability, permeability, cost-effectiveness, efficacy, and specificity compared to proteins, antibodies, and small organic molecules.
  • Peptide metabolism yields amino acids, resulting in lower toxicity and high selectivity.
  • Peptide-based drugs are promising for cancer mono- or polytherapy when combined with stabilizing modifications and novel delivery systems.

Conclusions:

  • Peptide-based drugs represent a promising frontier in oncology, offering enhanced efficacy and safety profiles.
  • Further investigation is crucial to address the potential oncogenic nature of some peptides and ensure therapeutic safety.
  • Ongoing preclinical and clinical studies are vital for advancing peptide therapeutics in cancer treatment.