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Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
Published on: May 25, 2018
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Genome Editing: Promoting Responsible Research
François Hirsch1,2, Christine Lemaitre3,4, Hervé Chneiweiss3,5,4,6,7,8
1Ethics Committee, Institut National de la Santé et de la Recherche Medicale (INSERM), Paris, France. francois.hirsch@inserm.fr.
Pharmaceutical Medicine
|January 15, 2020
Summary
Genome editing technologies like CRISPR have revolutionized molecular biology, offering accessible gene modification tools. This advancement necessitates global governance to address ethical and legal considerations for both scientists and the public.
Area of Science:
- Molecular Biology
- Biotechnology
- Bioethics
Background:
- Genome modification tools have existed for over 40 years, but progress was slow and limited to specialists.
- The advent of precision genome editing technologies, particularly CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat), has transformed the field.
- CRISPR technology has democratized gene modification, making it accessible, efficient, and cost-effective.
Purpose of the Study:
- To highlight the transformative impact of CRISPR technology on genome modification.
- To underscore the ethical and legal questions arising from widespread genome editing.
- To advocate for global governance in genome editing.
Main Methods:
- Review of historical developments in genome modification tools.
- Analysis of the impact and accessibility of CRISPR technology.
- Discussion of ethical, legal, and societal implications of genome editing.
Main Results:
- CRISPR has made genome modification fast, cheap, easy, and universally accessible.
- The popularization of human and other organism genome manipulation raises significant ethical and legal concerns.
- There is an urgent need for global governance to manage genome editing technologies.
Conclusions:
- CRISPR technology represents a paradigm shift in genome modification.
- Responsible innovation requires addressing the ethical and legal dimensions of genome editing.
- A coordinated global approach is essential for the responsible governance of genome editing technologies.
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