JAK2/STAT3 is associated with the inflammatory process in periapical granuloma

Area of Science:

• Immunology
• Molecular Biology
• Oral Pathology

Background:

• The Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway is implicated in various inflammatory diseases.
• Understanding the molecular mechanisms of periapical granuloma is crucial for developing targeted therapies.

Purpose of the Study:

• To investigate the association between the expression of JAK2, STAT3, and SOCS3 in periapical granuloma.
• To explore the role of these signaling molecules in the pathogenesis of periapical lesions.

Main Methods:

• Histological analysis, immunohistochemistry, and double immunofluorescence staining were performed on samples from 40 patients.
• Patients were categorized into healthy control (N=20) and periapical granuloma (N=20) groups.

Main Results:

• Periapical granuloma tissues exhibited significantly higher levels of JAK2, STAT3, phosphorylated JAK2 (p-JAK2), phosphorylated STAT3 (p-STAT3), and SOCS3 compared to healthy controls (P<0.05).
• Extensive inflammatory cell infiltration was noted in periapical granuloma samples.
• JAK2 and STAT3 positive cells were identified within the periapical lesion areas.

Conclusions:

• The study demonstrates the presence and potential association of JAK2, STAT3, and SOCS3 with the inflammatory process in periapical lesions.
• These findings offer novel insights into the pathological mechanisms underlying human periapical granuloma.