Xanthoma disseminatum: report of one case

An 8-year-old female had generalized papules and nodules for more than 6 years. Urine routine, blood lipid level, and cranial CT were normal. Histopathology of the lesion revealed that it consisted of abundant short spindle-shaped and epithelioid cell proliferation with foam cells and Touton giant cells. On immunohistochemistry, cells were CD68, CD31, and Ki-67<3% positive but were non-reactive to CK-pan, CD1a, and S-100. Diagnosis: xanthoma disseminatum.