Hodgkin's lymphoma with marked granulomatous reaction: a diagnostic pitfall

Hodgkin's lymphoma (HL) is a lymphoid malignant tumor characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells, the variants of which are reported to be involved in the inflammatory reaction. Epithelioid histiocytes, representing granuloma formation, often occur in the environment as single cells or clustered in nodules. This study was performed to report a case of HL in a cervical lymph node, accompanied by a notable granulomatous reaction. A granulomatous reaction might mask the presence of lymphomas, which is easily misdiagnosed as lymph node tuberculosis and other granulomatous lesions. This present case report may provide new insight for avoiding misdiagnosis of such lesions.