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Expression profiles and association between OATP4A1 and PGE2 in adenomyosis tissue
Deying Ban1, Chun Zhang1, Yi Zhang1
1Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University Changsha 410008, Hunan, People's Republic of China.
Objective:
To measure the expression of OATP4A1 and PGE2 in adenomyosis tissues, and to explore their roles in the incidence and development of adenomyosis-induced dysmenorrhea.
Methods:
OATP4A1 mRNA and protein in the Aadenomyosis tissues with/without dysmenorrhea and normal uterus were detected. The expression of PGE2 was measured.
Results:
OATP4A1 protein was mainly expressed on the cell membrane and in the cytoplasm of endometrial glandular cells. The IRS of OATP4A1 in the two adenomyosis groups were 3.030±1.903, and 5.200±1.789, significantly lower than 9.110±3.457 in the control group (both P<0.05). The expression levels of OATP4A1 protein in the endometrial-myometrial interface (EMI) of adenomyosis women were 15.217±6.106 and 20.085±3.633, considerably lower than 38.873±7.899 in the control group (both P<0.05). The expression levels of OATP4A1 mRNA in the adenomyosis groups were 0.593±0.281 and 0.805±0.440, significantly lower than 1.910±0.499 in the control group (both P<0.05). The expression levels of PGE2 in the three groups were 62.329±6.505, 45.099±3.192, 39.446±3.807 (pg/ml), respectively. OATP4A1 protein was negatively correlated with PGE2 expression in three groups (r = -0.598, P = 0.019; r = -0.967, P = 0.002; r = -0.663, P = 0.007).
Conclusion:
OATP4A1 is negatively correlated with PGE2, suggesting that low expression of OATP4A1 probably causes the topical accumulation of PGE2 which is proportional to the degree of pain.
