Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases
Can Cheng1, Zhenzhen Li1, Xu Zhao1
1Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China; Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, PR China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, PR China.
Abstract:
Once the balance between lipid anabolism and catabolism is broken, metabolic disorder will occur in the organism and finally lead to metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD), obesity and cancer. No established therapeutic regimens for treating NAFLD and obesity exist yet. Many natural compounds are extracted from botany, fungi and marine organisms. Importantly, natural compounds are major sources of innovative medicine. In this review, we first elucidate the important roles of lipid metabolism in NAFLD, obesity and cancer. Next, we summarize the action mechanisms of natural compounds including alkaloid, polyphenol targeting lipid metabolism. Therefore, manipulating lipid metabolism to reduce fatty acid availability may be the starting point for improving or even curing lipid metabolism-related diseases. Alkaloid and polyphenol are promising candidates for metabolic diseases to ameliorate lipid metabolism abnormalities.
Insights
Metabolic disorders like NAFLD and obesity arise from disrupted lipid metabolism. Natural compounds, particularly alkaloids and polyphenols, show promise in ameliorating these conditions by targeting lipid metabolism abnormalities.
Area of Science:
- Biochemistry
- Metabolic Diseases
- Pharmacology
Background:
- Disruption of lipid anabolism and catabolism balance leads to metabolic disorders.
- Metabolic diseases include nonalcoholic fatty liver disease (NAFLD), obesity, and cancer.
- Current therapeutic options for NAFLD and obesity are limited.
Purpose of the Study:
- To elucidate the role of lipid metabolism in NAFLD, obesity, and cancer.
- To summarize the mechanisms of action of natural compounds targeting lipid metabolism.
- To highlight the therapeutic potential of natural compounds for metabolic diseases.
Main Methods:
- Literature review of lipid metabolism in metabolic diseases.
- Analysis of natural compounds (alkaloids, polyphenols) affecting lipid metabolism.
- Review of therapeutic strategies targeting lipid metabolism.
Main Results:
- Lipid metabolism plays a critical role in the pathogenesis of NAFLD, obesity, and cancer.
- Alkaloids and polyphenols demonstrate significant potential in modulating lipid metabolism.
- Reducing fatty acid availability is a key strategy for treating metabolic diseases.
Conclusions:
- Natural compounds, especially alkaloids and polyphenols, are promising for treating metabolic diseases.
- Targeting lipid metabolism abnormalities offers a therapeutic avenue for NAFLD and obesity.
- Further research into natural compounds could lead to innovative treatments for metabolic disorders.
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