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Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
Ines Stevic1, Gustav Buescher2, Franz Lennard Ricklefs1
1Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Cells
|January 16, 2020
Summary
Extracellular vesicles (EVs), secreted by cells, are key in cell communication and cancer progression. This review explores their potential for monitoring cancer therapy effectiveness.
Area of Science:
- Biochemistry and Molecular Biology
- Cell Biology
- Oncology
Background:
- Extracellular vesicles (EVs) are cell-secreted, membrane-bound vesicles containing various biomolecules.
- EVs are implicated in intercellular communication and have roles in cancer progression and metastasis.
- They are found in body fluids and hold potential as diagnostic biomarkers.
Purpose of the Study:
- To review the potential of extracellular vesicles (EVs) in monitoring cancer therapy efficacy.
- To highlight the role of EVs as biomarkers for cancer diagnosis and treatment response.
Main Methods:
- Literature review of studies on extracellular vesicles in cancer therapy.
- Analysis of research on EV composition and function in relation to cancer.
- Synthesis of evidence regarding EV-based monitoring of treatment response.
Main Results:
- EVs contain proteins, DNA, and RNA, mediating cell-to-cell communication.
- EVs play significant roles in cancer progression and metastasis.
- Emerging evidence supports the therapeutic potential of EVs.
Conclusions:
- Extracellular vesicles show promise as biomarkers for early cancer diagnosis and real-time monitoring of treatment.
- Further research into EVs could lead to novel therapeutic strategies in oncology.
- EVs are valuable tools for assessing the efficacy of cancer treatments.
