Related Experiment Video

Updated: Dec 31, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

9.8K

TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease

Débora Falcón1,2, Isabel Galeano-Otero1, Marta Martín-Bórnez1

  • 1Department of Medical Physiology and Biophysics, Institute of Biomedicine of Seville, University of Seville, 41013 Seville, Spain.

Cells
|January 16, 2020
PubMed

Insights

Transient receptor potential canonical (TRPC) channels are vital in heart health, particularly during ischemia and infarction. Their dysfunction contributes to cardiovascular diseases by altering calcium levels and promoting detrimental cellular responses.

Area of Science:

  • Cardiovascular Biology
  • Ion Channel Physiology
  • Molecular Medicine

Background:

  • Transient receptor potential canonical (TRPC) channels are crucial ion channels in cardiac cells, sensing diverse stimuli.
  • TRPC channels can form complexes with other proteins, regulating intracellular calcium (Ca2+).
  • TRPC channel dysfunction is implicated in various cardiovascular diseases.

Purpose of the Study:

  • To review the role of TRPC channels in cardiac ischemia and reperfusion.
  • To highlight TRPC channel involvement in heart infarction processes.
  • To summarize current knowledge on TRPC-mediated cellular responses to cardiac injury.

Main Methods:

  • Literature review of studies on TRPC channels in cardiovascular disease models.
  • Analysis of experimental data from animal models of heart infarcts.
  • Examination of in vitro studies on ischemia and reperfusion.

Main Results:

  • TRPC expression significantly increases in models of heart infarcts, ischemia, and reperfusion.
  • TRPC-mediated Ca2+ influx is essential for activating signaling pathways in stressed hearts.
  • These pathways contribute to cardiac hypertrophy, fibrosis, and angiogenesis post-injury.

Conclusions:

  • TRPC channels play a significant role in the heart's response to ischemia and infarction.
  • Targeting TRPC channels may offer therapeutic strategies for cardiovascular diseases.
  • Further research is needed to fully elucidate TRPC channel functions in cardiac pathology.
Keywords:
Ca2+ entryTRPC channelcardiac infarctioncardiac repair

More Related Videos

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.6K
Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b10:20

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

8.9K

Related Concept Videos

Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
1.2K
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.8K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
309
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.7K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.5K
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
1.4K