Sinonasalteratocarcinosarcoma: a report of two cases and clinicopathological analysis

Sinonasalteratocarcinosarcoma (SNTCS) is a highly malignant and aggressive neoplasm which can quickly damage the local soft tissue, bone tissue, and invade orbital and intracranial tissues. It also can result in local lymph node and distant organ metastasis. The data from 2 cases of SNTCS from the First Affiliated Hospital of Bengbu Medical College (China), treated with radiotherapy and chemotherapy followed by cranio-facial resection, were analyzed since 2016. The main symptoms of the two patients were of the nasal cavity with nasal congestion and runny nose. There was no recurrence after surgery. Microscopic examination showed that the composition of tumor tissue was very complex, as different degrees of differentiation of the origin of the organization could be seen in the tumor tissue. It was mixed with teratoma and cancer sarcoma components and undifferentiated/primitive tumor cells could also be seen in local tumor stroma. SNTCS is a very rare complex tissue composition of malignant tumors, because of its complex pathological morphology and high possibility of misdiagnosis. Pathological features and immunohistochemical markers can contribute to the diagnosis and differential diagnosis of the disease.