Development of a miniature and ASIC based impedance cardiograph

In view of cardiac output monitoring application of impedance cardiography a miniature impedance cardiograph has been developed, which is based on an application specific integrated circuit (analog front end chip AFE4300). Carrier current capability of this chip has been enhanced four times (up to 3.2 milliamperes) for cardiology applications with the help of an external resistance, not provisioned in the original design. Also the sensed signal is externally amplified before feeding to AFE chip to increase resolution in the impedance range of 10-50 Ohms.The AFE chip is interfaced to a Personal Computer with the help of a microcontroller board through a USB cable. Application software programs the AFE chip for sending a carrier current of 3.2 milliamperes (peak to peak) to the subject's body segment through current output ports and sensing the chest impedance through voltage input ports. The chest impedance is read in detector mode and communicated to Laptop through serial peripheral interface of the chip. Chest impedance, change in impedance as a function of time and rate of change of impedance are displayed on the graphic user interface. Fifteen minute data from volunteers have shown consistent recordings, as described in this paper.