Related Experiment Video
Updated: Dec 30, 2025
09:36
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
26.1K
Long noncoding RNAs in neurodevelopment and Parkinson's disease
Ying Lyu1, Lin Bai1, Chuan Qin1
1Institute of Medical Laboratory Animal Science Chinese Academy of Medical Sciences & Comparative Medical Center Peking Union Medical College Beijing China.
Animal Models and Experimental Medicine
|January 17, 2020
Summary
Long noncoding RNAs (lncRNAs) regulate crucial biological processes. This review explores their role in neurodevelopment and Parkinson's disease pathogenesis, offering insights for diagnosis and treatment.
Area of Science:
- Molecular Biology
- Neuroscience
- Genetics
Background:
- Long noncoding RNAs (lncRNAs) are key regulators of gene expression.
- lncRNAs influence diverse biological processes, including development and disease.
- Their specific roles in neurological functions and Parkinson's disease (PD) require further elucidation.
Purpose of the Study:
- To review the multifaceted roles of lncRNAs in neurodevelopment.
- To examine the involvement of lncRNAs in the pathogenesis of Parkinson's disease (PD).
- To highlight the potential of lncRNAs for PD diagnosis and therapeutic strategies.
Main Methods:
- Literature review of studies on lncRNAs.
- Analysis of lncRNA involvement in neurodevelopmental processes.
- Investigation of lncRNA contributions to PD pathomechanisms.
Main Results:
- lncRNAs are implicated in neurodevelopment, neural differentiation, and synaptic function.
- Specific lncRNAs are linked to PD pathomechanisms such as protein aggregation, mitochondrial dysfunction, and neuroinflammation.
- Dysregulation of lncRNAs contributes to the complex pathology of Parkinson's disease.
Conclusions:
- lncRNAs play critical roles in normal brain function and neurological disorders.
- Understanding lncRNA functions provides a basis for novel diagnostic markers for PD.
- lncRNAs represent promising targets for developing new therapeutic interventions for Parkinson's disease.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.6K
02:39lncRNA - Long Non-coding RNAs
3.4K
3.4K
01:37Neural Regulation
43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
01:15Parkinson's Disease: Overview
1.6K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.6K
01:20Types of RNA
8.7K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
8.7K
01:24Parkinson's Disease: Treatment
886
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
886