Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

9.1K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
9.1K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

11.5K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
11.5K
Antimicrobial Proteins01:23

Antimicrobial Proteins

12.8K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.8K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.0K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.0K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.6K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.6K
Antibody Actions01:26

Antibody Actions

2.2K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of triumeq treatment on a TDP-43 mouse model of amyotrophic Lateral sclerosis.

Scientific reports·2026
Same author

<i>Nocardia</i> Infection Presented as Intramuscular Abscess in a Kidney Transplant Recipient: Case Report and Literature Review.

Case reports in nephrology·2025
Same author

Revisiting the monocrotaline-treated rat as a model of inflammatory lung disease: COVID-19 and future pandemic threats?

Animal models and experimental medicine·2025
Same author

Coatomer protein complex I is required for efficient secretion of dengue virus non-structural protein 1.

Journal of virology·2025
Same author

A F<sub>420</sub>-dependent Single Domain Chemogenetic Tool for Protein De-dimerization.

Journal of molecular biology·2025
Same author

Twelfth scientific biennial meeting of the Australasian Virology Society: AVS12 2024.

Journal of virology·2025
Same journal

Identification of a Shiga toxin A-derived peptide internalized into Gb3 receptor-bearing cells via interaction with the Shiga toxin B subunit.

FEBS letters·2026
Same journal

The dual role of lectins in cancer-immunotherapy tools and therapeutic targets.

FEBS letters·2026
Same journal

Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression.

FEBS letters·2026
Same journal

Extending the classical sequence-structure-function paradigm through protein dynamics and context-dependent behavior.

FEBS letters·2026
Same journal

α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates.

FEBS letters·2026
Same journal

Modelling stem cell differentiation related processes-A practical overview for biologists.

FEBS letters·2026
See all related articles

Related Experiment Video

Updated: Dec 30, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.0K

Dengue virus and the complement alternative pathway.

Jillian M Carr1, Sheila Cabezas-Falcon1,2, Joshua G Dubowsky1

  • 1College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

FEBS Letters
|January 17, 2020
PubMed
Summary
This summary is machine-generated.

Severe dengue involves complement alternative pathway (AP) overactivation, leading to vascular leakage. Targeting this AP dysfunction may offer new treatments for severe dengue, similar to atypical hemolytic uremic syndrome (aHUS).

Keywords:
alternative pathwaycomplementcomplement factor Bcomplement factor Hdengue virus

More Related Videos

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum
07:06

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum

Published on: April 10, 2018

9.1K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.9K

Related Experiment Videos

Last Updated: Dec 30, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.0K
A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum
07:06

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum

Published on: April 10, 2018

9.1K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.9K

Area of Science:

  • Immunology
  • Pathology
  • Virology

Background:

  • Dengue disease is an inflammatory condition linked to complement system overactivation and increased vascular leakage.
  • Dysregulation of the complement alternative pathway (AP), including complement factor D upregulation and complement factor H (FH) downregulation, is observed in severe dengue.
  • AP activation typically protects against viral infections but may contribute to dengue pathology.

Purpose of the Study:

  • To investigate the role of complement alternative pathway (AP) dysfunction in severe dengue pathogenesis.
  • To explore potential therapeutic strategies targeting AP overactivation in dengue.

Main Methods:

  • Analysis of AP activation in dengue virus-infected macrophages and endothelial cells (ECs).
  • Comparison of dengue AP dysregulation with complement pathologies like atypical hemolytic uremic syndrome (aHUS).

Main Results:

  • The AP is activated in dengue virus-infected macrophages and ECs.
  • Dengue disease exhibits AP activation, reduced FH levels, and vascular leakage, mirroring features of FH deficiency-associated aHUS.
  • This suggests AP dysfunction contributes to severe dengue pathology.

Conclusions:

  • Severe dengue pathology may stem partly from AP dysfunction.
  • Therapeutic strategies targeting complement terminal activity, like those used for aHUS, could be beneficial for severe dengue.
  • Inhibiting complement or delivering FH to ECs may combat vascular leakage in severe dengue.