Related Experiment Video
Updated: Dec 30, 2025
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Ruthenium-Induced Cyclization of Heteroatom-Functionalized Alkynes: Progress, Challenges and Perspectives
Lai-Hon Chung1, Chi-Fung Yeung1,2, Chun-Yuen Wong1,2
1Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, SAR, P. R. China.
Abstract:
Metal-induced cyclization of functionalized alkynes represents one of the most general approaches to prepare organic heterocycles. Although RuII centers are well-established to promote alkyne to vinylidene rearrangements and many RuII -mediated alkyne cyclizations have been rationalized to be the results of post-vinylidene transformations, recent discoveries indicate that RuII centers can serve as electrophiles and induce alkyne cyclizations without vinylidene intermediacy. In this Minireview, an overview of the RuII -induced cyclization of heteroatom-functionalized alkynes in the last decade is provided, with an emphasis on the discoveries and validations of the unconventional "non-vinylidene-involving" pathways.
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