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Updated: Dec 30, 2025

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
[Strategies in Crohn's disease treatment - "step-up" vs. "top-down"]
Marta Piotrowska1, Julia Krajewska2, Jakub Fichna3
1Zakład Biochemii, Wydział Lekarski, Uniwersytet Medyczny w Łodzi. m.piotrowska97@gmail.com.
Abstract:
Inflammatory bowel diseases (IBD) are chronic conditions that lead to serious complications and act to the detriment of quality of patients' lives. Etiology of IBD has not been precisely determined but it is assumed that IBD is caused by genetic, immune and environmental factors. The main target in current IBD treatment is the induction and maintenance of remission. The most common strategy in IBD therapy is called "step-up" that is based on gradual introduction of stronger drugs. However, the latest research shows that "top down" strategy is more promising and can change the natural course of the disease. The aim of this article is to discuss both strategies and compare their effectiveness.
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