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Profiling Maternal Behavior Responses During Whole-Brain Imaging
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Fetal Response to a Maternal Internal Auditory Stimulus.

Estee Goldberg1, Charles A McKenzie1,2,3, Barbra de Vrijer3,4

  • 1Biomedical Engineering, Western University, London, Ontario, Canada.

Journal of Magnetic Resonance Imaging : JMRI
|January 18, 2020
PubMed
Summary

Maternal singing activates fetal auditory networks during functional MRI (fMRI). This safe, internal stimulus reliably engages the primary auditory cortex, offering new insights into in-utero brain development.

Keywords:
auditory task stimulusbrain developmentfetal fMRI

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Functional MRI (fMRI) is crucial for studying brain development.
  • Fetal brain development insights are limited due to challenges in in-utero investigation.
  • Previous external auditory stimuli for fetal fMRI were deemed unsafe.

Purpose of the Study:

  • To establish a safe and reliable method for studying fetal brain network development.
  • To investigate the use of maternal singing as an internal auditory stimulus in fetal fMRI.
  • To identify activation in the fetal primary auditory cortex using this novel paradigm.

Main Methods:

  • Nine pregnant women (33-38 weeks) underwent task-based block design fMRI at 1.5T or 3T.
  • Maternal singing was used as an internal auditory stimulus.
  • fMRI data were analyzed for fetal motion, corrected, and assessed for activation in a gestational age-matched atlas.

Main Results:

  • Auditory stimulus from maternal singing activated the primary auditory cortex (Heschl's gyrus) in most fetuses.
  • Activation was observed in the right Heschl's gyrus (8 subjects) and left Heschl's gyrus (6 subjects).
  • Additional activation was noted in the middle cingulate cortex and left putamen.

Conclusions:

  • Maternal singing serves as a safe and effective internal stimulus for fetal fMRI.
  • This method reliably activates the fetal auditory network, including Heschl's gyrus.
  • Provides a novel approach to understanding in-utero auditory processing and brain development.