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Updated: Dec 30, 2025
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Estimating patient-reported outcomes for glaucoma management: A cross-sectional study
Lavanya Uruthiramoorthy1,2, Cindy M L Hutnik2,3, Kathy N Speechley1,2,4
1Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Journal of Evidence-Based Medicine
|January 18, 2020
Summary
Clinical and demographic factors like mobility aid use and visual acuity predict glaucoma patient quality of life, but don't fully capture individual experiences. Routine patient-reported outcome collection is recommended.
Area of Science:
- Ophthalmology
- Public Health
- Health Services Research
Background:
- Glaucoma significantly impacts patients' quality of life.
- Understanding factors influencing patient-reported outcomes (PROs) is crucial for comprehensive care.
Purpose of the Study:
- To identify key explanatory variables for vision-related quality of life (VRQoL), health-related quality of life (HRQoL), social support, community integration, and depressive symptoms in glaucoma patients.
- To assess the predictive power of commonly collected clinical and demographic data on these PROs.
Main Methods:
- Cross-sectional study of 250 glaucoma or glaucoma suspect patients at an ophthalmic practice.
- Data collected via medical chart review and interviews using validated PRO tools.
- Predictive models developed using regression and tree-based methods, validated with leave-one-out cross-validation.
Main Results:
- Mobility aid use, best corrected visual acuity (BCVA), income, and living arrangements were significant predictors for VRQoL, social support, and community integration.
- Mobility aid use also predicted depressive symptoms, while BCVA predicted preference-based HRQoL.
Conclusions:
- Clinical and demographic variables show associations with PROs but have limited accuracy in predicting individual patient outcomes.
- Routine collection of PROs is suggested to gain a complete understanding of glaucoma patients' quality of life.
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