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Do progenitors play dice?

Esther Klingler1, Denis Jabaudon1,2

  • 1Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.

Elife
|January 18, 2020
PubMed
Summary
This summary is machine-generated.

Single progenitors in mouse neocortex generate diverse cell types through random, stochastic processes, not predetermined, deterministic ones. This finding impacts our understanding of brain development and cellular differentiation.

Keywords:
cell fatecell lineagescortical developmentdevelopmental biologymodellingmouseneocortexneuronneuroscience

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The neocortex exhibits remarkable cellular diversity.
  • Understanding the mechanisms generating this diversity is crucial for developmental neuroscience.

Purpose of the Study:

  • To investigate whether the diverse cell types arising from single neocortical progenitors are generated by stochastic or deterministic processes.

Main Methods:

  • Utilized lineage tracing in mouse models.
  • Analyzed progenitor behavior and resulting cell types in the developing neocortex.

Main Results:

  • Observed a wide spectrum of cell types originating from individual progenitor cells.
  • Data suggests that cell fate decisions are not strictly predetermined.

Conclusions:

  • The generation of diverse neocortical cell types from single progenitors likely involves stochastic mechanisms.
  • This implies a degree of randomness in early brain development and cellular differentiation.