[The effect of ethanol on the initial stage of protein biosynthesis in the rat liver]

After administration of ethanol into rats at a dose of 1.63 g/kg of body mass within two weeks the rate of sRNA aminoacylation was decreased if 14C-leucine and 14C chlorella protein hydrolysate were used. Addition of the alcohol into incubation media caused the ethanol-dependent inhibition of sRNA aminoacylation by valine. leucine, proline, histidine as well as by amino acid mixture from the protein hydrolysate. At the same time, aminoacylation of sRNA by glycine and aspartic acid was unaltered. The rate of sRNA aminoacylation by aspartic acid was increased in presence of 85 mmole of ethanol.