An Axonal Blueprint: Generating Neuronal Polarity with Light-Inducible Proteins
1Stanford University Department of Neurobiology, Stanford, CA 94305, USA; Stanford University Department of Bioengineering, Stanford, CA 94305, USA; Stanford University Department of Chemical and Systems Biology, Stanford, CA 94305, USA; Stanford University Department of Pediatrics, Stanford, CA 94305, USA.
Cell Chemical Biology
|January 18, 2020
Abstract:
In this issue of Cell Chemical Biology, Woo et al. (2019) show that activation of a photoinducible form of the TrkB protein in a single neurite induces multiple aspects of axonal differentiation. This study exemplifies the ability of optical methods to relate protein functions to complex phenotypes in living cells.
