Related Experiment Video
Updated: Oct 17, 2026
10:24
Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells
Published on: December 17, 2012
Location, location, deUFMylation: Coordinating ribosome quality control at the ER
Alexander R Mikesell1, Zachary T Campbell1
1Department of Anesthesiology, University of Wisconsin - Madison, Madison, WI, USA.
Cell Chemical Biology
|October 15, 2026
Abstract:
Endoplasmic-reticulum-associated ribosome quality control (ER-RQC) requires ubiquitin-fold modifier 1 (UFM1) for UFMylation of the ribosomal protein RPL26. In the August 6 issue of Molecular Cell, Mao et al.1 identify an ER-associated complex (UFSP2/ODR4) as critical for deUFMylation of RPL26 and uncover a critical physiologic role for UFSP2 in neuronal proteostasis.
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