Related Experiment Video
Updated: Dec 30, 2025

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
Published on: June 9, 2016
Magnetic Susceptibility Difference-Induced Nucleus Positioning in Gradient Ultrahigh Magnetic Field
Qingping Tao1, Lei Zhang2, Xuyao Han3
1High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China; Science Island Branch of Graduate School, University of Science and Technology of China, Hefei, China.
Abstract:
Despite the importance of magnetic properties of biological samples for biomagnetism and related fields, the exact magnetic susceptibilities of most biological samples in their physiological conditions are still unknown. Here we used superconducting quantum interferometer device to detect the magnetic properties of nonfixed, nondehydrated live cell and cellular fractions at a physiological temperature of 37°C (310 K). It is obvious that there are paramagnetic components within human nasopharyngeal carcinoma CNE-2Z cells. More importantly, the magnetic properties of the cytoplasm and nucleus are different. Although within a single cell, the magnetic susceptibility difference between cellular fractions (nucleus and cytoplasm) could only cause ∼41-130 pN forces to the nucleus by gradient ultrahigh magnetic fields of 13.1-23.5 T (92-160 T/m), these forces are enough to cause a relative position shift of the nucleus within the cell. This not only demonstrates the importance of magnetic susceptibility in the biological effects of magnetic field but also illustrates the potential application of high magnetic fields in biomedicine.
More Related Videos
Related Concept Videos
Atomic Nuclei: Nuclear Magnetic Moment
Atomic Nuclei: Magnetic Resonance
Atomic Nuclei: Nuclear Relaxation Processes
Atomic Nuclei: Nuclear Spin State Overview
Atomic Nuclei: Nuclear Spin State Population Distribution
Diamagnetic Shielding of Nuclei: Local Diamagnetic Current

