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Updated: Dec 30, 2025

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Macrocyclic cyanocobalamin (vitamin B12) as a homogeneous electrocatalyst for water oxidation under neutral
Hossain M Shahadat1, Hussein A Younus, Nazir Ahmad
1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China. francis.verpoort@ugent.be.
Abstract:
Highly water-soluble cyanocobalamin (also known as vitamin B12) is the most structurally macrocyclic complex comprising cobalt in the center of a corrin ring. Interestingly, it acts as a robust electrocatalyst in water oxidation at ∼0.58 V overpotential with a faradaic efficiency of 97.50% under neutral buffered conditions. The catalyst is impressively stable even after long-term bulk electrolysis, and homogeneous in nature, as established by a series of experiments and characterization techniques.
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