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Correlation between serum IL 37 levels with keloid severity
Fathia M Khattab1, Mai A Samir1
1Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Journal of Cosmetic Dermatology
|January 22, 2020
Summary
Lower levels of Interleukin 37 (IL-37) correlate with increased keloid severity. This finding suggests IL-37 may serve as a biomarker for keloid progression.
Area of Science:
- Dermatology
- Immunology
- Fibroproliferative Disorders
Background:
- Keloids are characterized by excessive extracellular matrix deposition.
- Interleukin 37 (IL-37) inhibits keloid fibroblast proliferation and extracellular matrix production.
- IL-37 shows potential for early keloid prevention strategies.
Purpose of the Study:
- To investigate the relationship between serum IL-37 levels and keloid severity.
- To determine if IL-37 levels can predict keloid progression.
Main Methods:
- Cross-sectional study of 32 keloid patients.
- Keloid severity assessed using the Vancouver Scar Scale (VSS).
- Serum IL-37 levels measured and correlated with VSS scores.
Main Results:
- A significant negative correlation was observed between IL-37 levels and keloid severity (r = -0.737, P = .0001).
- No significant correlation found between IL-37 levels and patient age, gender, lesion duration, or family history.
Conclusions:
- Lower plasma IL-37 levels are associated with increased keloid severity.
- IL-37 may serve as a potential biomarker for keloid severity.
