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Cobamides.

Kristopher J Kennedy1, Michiko E Taga1

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|January 22, 2020
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This summary is machine-generated.

Vitamin B12, an essential human nutrient, and related cobamides are exclusively synthesized by prokaryotes. These cobalt-containing compounds highlight the crucial role of microbes in providing vital nutrients.

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Area of Science:

  • Microbiology
  • Biochemistry
  • Human Nutrition

Background:

  • Vitamin B12 is an essential human micronutrient.
  • Its synthesis is exclusively performed by prokaryotic microorganisms.
  • Cobalamins, a class of cobalt-containing compounds, include Vitamin B12.

Purpose of the Study:

  • To introduce the significance of cobamides, including Vitamin B12.
  • To highlight the exclusive microbial production of these essential compounds.
  • To underscore the symbiotic relationship between humans and microbes for nutrient acquisition.

Main Methods:

  • Review of existing literature on Vitamin B12 and cobamide synthesis.
  • Analysis of the biochemical pathways involved in microbial cobamide production.
  • Discussion of the ecological and evolutionary aspects of cobamide biosynthesis.

Main Results:

  • Prokaryotes are the sole biological source of Vitamin B12 and related cobamides.
  • Cobamides represent a unique class of cobalt-dependent biomolecules.
  • Microbial synthesis is critical for the availability of these micronutrients to other organisms.

Conclusions:

  • Vitamin B12 and cobamides are exclusively produced by prokaryotes.
  • These microbial contributions are vital for human health and nutrition.
  • Understanding microbial synthesis pathways offers insights into nutrient cycling and host-microbe interactions.