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D2 dopamine receptors in rat striatum are homogeneous as revealed by ligand-binding studies
M N Leonard1, C A Halliday, A S Marriott
1Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
Biochemical Pharmacology
|November 15, 1988
Abstract:
D2 dopamine receptors in rat striatum have been analysed using the binding of [3H]domperidone. Competition experiments were performed with classical dopamine antagonists and antagonists reported by other workers to discriminate D2 dopamine receptor sub-classes. In all cases competition data conformed to a single binding site interaction so that there is no evidence for heterogeneity of the D2 dopamine receptor.