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Drug-protein interactions. On the protein-protein interaction induced by levamisole in vitro. A mechanism hypothesis
M Chicault1, C Luu Duc, A Boucherle
1Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.
Arzneimittel-Forschung
|October 1, 1988
Abstract:
In the present communication, a model is reported in order to explain the aggregation of albumin induced by levamisole in vitro. The hypothesis suggests that the process of polymerization of albumins may include ligand-protein interaction as a biochemical catalysis, and covalent protein-protein interactions by a mechanism of disulfide-sulfhydryl interchange by intramolecular or intermolecular reactions.