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Usefulness Of Neutrophils To Lymphocytes Ratio For Predicting Troponin-I Elevation In Patients Presenting With

Muhammad Saleem Awan1, Muhammad Yousuf Daud1, Matiullah Khan1

  • 1Department of Cardiology, Ayub Teaching Hospital, Abbottabad, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|January 23, 2020
PubMed

Insights

The Neutrophils to Lymphocyte Ratio (NLR) strongly correlates with elevated Troponin-I levels in Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients. This inflammatory marker can predict cardiac Troponin-I elevation in suspected NSTE-ACS cases.

Area of Science:

  • Cardiology
  • Inflammation and Cardiovascular Disease
  • Biomarkers in Acute Coronary Syndrome

Background:

  • Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) accounts for most coronary care unit admissions.
  • Inflammation plays a key role in the pathogenesis of acute coronary syndrome.
  • The Neutrophils to Lymphocyte Ratio (NLR) is an emerging inflammatory marker and predictor of cardiovascular events.

Purpose of the Study:

  • To investigate the diagnostic role of the Neutrophils to Lymphocyte Ratio (NLR).
  • To determine if NLR can predict Troponin-I elevation in patients with suspected NSTE-ACS.

Main Methods:

  • A descriptive case series study was conducted.
  • 203 patients with suspected NSTE-ACS were enrolled using consecutive sampling.
  • Data was collected from May 2017 to December 2018.

Main Results:

  • A strong correlation was observed between the Neutrophils to Lymphocyte Ratio (NLR) and elevated Troponin-I levels.
  • The 4th quartile of NLR demonstrated high specificity (97.8%) and a high positive predictive value (96.7%) for predicting Troponin-I rise.

Conclusions:

  • The Neutrophils to Lymphocyte Ratio (NLR) is strongly correlated with cardiac Troponin-I elevation in suspected NSTE-ACS.
  • NLR can serve as a valuable predictive parameter for Troponin-I levels in NSTE-ACS patients.
Abstract

Keywords:
Non-ST segment elevation myocardial infarction (NSTEMI); ST-segment depressionElectrocardiogramNeutrophils to Lymphocytes ratio; Non-ST elevation acute coronary syndrome

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