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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: Dec 30, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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A roadmap to precision medicine for multiple sclerosis.

Tanuja Chitnis1, Alexandre Prat2

  • 1Tanuja Chitnis Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA/Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|January 23, 2020
PubMed
Summary

Precision medicine offers improved care for multiple sclerosis (MS) by classifying subtypes based on biology. Emerging biomarkers aid in tailoring treatment decisions for MS patients, enhancing disease management.

Keywords:
Multiple sclerosisbiomarkersdisabilitypatientprecision medicine

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Area of Science:

  • Neurology
  • Immunology
  • Genetics

Background:

  • Multiple sclerosis (MS) is a leading cause of neurological disability in young adults, affecting approximately 1 million individuals in the U.S.
  • MS presents with diverse clinical phenotypes and varying severity, indicating underlying biological heterogeneity.
  • Current management relies on over 18 approved disease-modifying therapies, with a growing need for personalized treatment strategies.

Purpose of the Study:

  • To provide an overview of precision medicine concepts applied to multiple sclerosis.
  • To discuss emerging biological markers and their role in MS management.
  • To highlight the potential of precision medicine to improve patient outcomes in MS.

Main Methods:

  • Review of current literature on precision medicine in neurology.
  • Analysis of emerging biomarkers for treatment response in multiple sclerosis.
  • Discussion of the integration of biological data into clinical decision-making for MS.

Main Results:

  • Precision medicine aims to classify MS subtypes based on underlying biology, moving beyond clinical phenotypes alone.
  • Several biomarkers are emerging as indicators of treatment response in MS.
  • Understanding biological underpinnings of MS phenotypes is crucial for personalized care.

Conclusions:

  • Precision medicine holds significant promise for advancing the care and management of multiple sclerosis.
  • Emerging biomarkers are key to tailoring therapeutic interventions for individual MS patients.
  • The integration of precision medicine principles is expected to refine decision-making processes in MS treatment.