Related Experiment Video
Updated: Dec 30, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
CHI3L1 is correlated with childhood asthma
Feng Chen1, Yuan An2, Juan Wang2
1Department of Internal Medicine, Xi'an Children's Hospital Xi'an 710003, Shaanxi, China.
Objective:
The aim of this study was to assess the association between CHI3L1 gene two single nucleotide polymorphisms (SNPs) (rs12141494 and rs4950928) and susceptibility to pediatric asthma in a Chinese Han population.
Methods:
The case-control study was carried out on 115 children with asthma and 108 healthy controls. Genotypes of rs12141494 and rs4950928 within CHI3L1 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. Chi-square test was employed to analyze the differences of genotype and allele frequencies of the two polymorphisms between case and control groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to explain relative susceptibility of pediatric asthma.
Results:
The frequencies of genotypes and alleles of rs4950928 in CHI3L1 gene showed a significant difference between asthmatic children and healthy controls (P<0.05). However, no significant differences were found in CHI3L1 SNP rs12141494 between two groups (P>0.05).
Conclusion:
Our results suggested that rs4950928 in CHI3L1 gene was associated with pediatric asthma risk in a Chinese Han population, while rs12141494 was not.
More Related Videos
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
05:53Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Related Concept Videos
Asthma-I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms: