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Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Related Experiment Video

Updated: Dec 30, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
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Lichen extracts regulate the expression of BMP7 via miR-194-5p targeting to decrease the risk atrial fibrillation.

Kailin Zhao1, Liyun Xiao2, Meili Zhao2

  • 1Department of Cardiology, Yantai Yeda Hospital Shandong, China.

International Journal of Clinical and Experimental Pathology
|January 23, 2020
PubMed
Summary

Lichen extracts may help regulate genes associated with atrial fibrillation (AF) by decreasing miR-194-5p and increasing BMP7 expression. This finding offers potential new strategies for managing this common heart arrhythmia.

Keywords:
Atrial fibrillationBMP7lichenmiR-194-5ptraditional Chinese herbal preparation

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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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Area of Science:

  • Cardiology
  • Genetics
  • Pharmacology

Background:

  • Atrial fibrillation (AF) is a prevalent cardiac arrhythmia affecting millions globally.
  • Genetic factors are increasingly recognized as significant contributors to AF pathogenesis.
  • Understanding AF's genetic mechanisms is crucial for improved risk stratification and treatment.

Purpose of the Study:

  • To investigate the effects of Lichen extracts on gene expression in cardiac cells.
  • To explore the role of miR-194-5p and BMP7 in Lichen's impact on cardiac myocytes.
  • To determine if Lichen can modulate AF-associated genes.

Main Methods:

  • Immunofluorescence staining was used to assess cellular components.
  • Expression levels of BMP7 and miR-194-5p were measured in Human Cardiac Myocytes (HCM) after Lichen treatment.
  • mRNA levels were analyzed under conditions of normal and overexpressed miR-194-5p.

Main Results:

  • Lichen extract treatment (20 µg/mL for 48 hours) significantly reduced Collagen I expression.
  • Lichen altered gene expression in H9c2 cells, with BMP7 identified as a target of miR-194-5p.
  • Lichen suppressed miR-194-5p and increased BMP7 expression in HCM, irrespective of miR-194-5p overexpression.

Conclusions:

  • Lichen extracts demonstrate a regulatory effect on AF-associated genes.
  • The mechanism involves miR-194-5p targeting, leading to altered BMP7 expression.
  • This suggests a potential therapeutic role for Lichen in managing atrial fibrillation.