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Updated: Dec 30, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Correlates of Cognitive Function in Sickle Cell Disease: A Meta-Analysis
Kemar V Prussien1, Rachel E Siciliano1, Abagail E Ciriegio1
1Department of Psychology and Human Development, Vanderbilt University.
Biological, environmental, and behavioral factors correlate with cognitive function in sickle cell disease (SCD). Higher hemoglobin, hematocrit, and socioeconomic status are linked to better cognitive outcomes, while behavioral problems indicate lower cognitive function.
Area of Science:
- Neuroscience
- Hematology
- Psychology
Background:
- Sickle cell disease (SCD) is a genetic blood disorder impacting cognitive function.
- Understanding the correlates of cognitive impairment in SCD is crucial for developing targeted interventions.
Purpose of the Study:
- To conduct a comprehensive quantitative review of biological, environmental, and behavioral factors associated with cognitive function in individuals with SCD.
Main Methods:
- A meta-analysis of 47 studies involving 2573 participants with SCD was performed.
- Data were sourced from PubMed, MedLine, and PsycINFO databases.
Main Results:
- Hemoglobin and hematocrit showed positive correlations with Full Scale IQ (FSIQ), language, and executive function.
- Socioeconomic status was positively associated with all cognitive domains assessed.
- Higher behavioral problems were linked to lower FSIQ.
Conclusions:
- Biological, environmental, and psychosocial factors significantly correlate with cognitive function in SCD.
- Further research is needed to explore specific cognitive domains and psychosocial correlates, including interactional models of risk factors.
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