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Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

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Block Copolymer Nanosystems Encapsulating Magnetic Nanoparticles and Drug.

E Vlassi¹, A Papagiannopoulos², A Sergides²

¹Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.

Journal of Nanoscience and Nanotechnology

|January 24, 2020

Summary

This study developed versatile magnetic nanosystems using self-assembling copolymers and iron oxide nanoparticles. These stable hybrid systems show potential for bio-imaging and drug delivery in aqueous environments.

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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Published on: March 2, 2020

Area of Science:

Materials Science
Nanotechnology
Polymer Chemistry

Background:

Amphiphilic diblock copolymers self-assemble into nanosystems.
Encapsulating nanoparticles within these systems creates hybrid materials.
Controlling solution behavior is crucial for biomedical applications.

Purpose of the Study:

Investigate the solution behavior of copolymer-nanoparticle hybrid nanosystems.
Evaluate stability under physiological conditions and in serum protein mixtures.
Assess the potential for drug encapsulation and delivery.

Main Methods:

Synthesis of poly(ethylene oxide-b-phenyl oxazoline) (PEO-b-PPhOx) and poly(isoprene-b-ethylene oxide) (PI-b-PEO) copolymers.
Encapsulation of iron oxide nanoparticles (γ-Fe₂O₃).
Light scattering techniques to analyze aggregate size and mass in various solutions over time.

Main Results:

Developed stable hybrid nanosystems with encapsulated magnetic nanoparticles.
Demonstrated successful entrapment of the anti-inflammatory drug indomethacin.
Observed distinct solution behavior under different conditions and storage times.

Conclusions:

Versatile nanosystems combining metal oxide and copolymer characteristics were created.
These hybrid systems exhibit potential for bio-imaging applications.
The nanosystems show promise for drug delivery in aqueous media.