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Published on: May 12, 2020
Cyclam-based antibacterial molecules eradicate Gram-negative superbugs with potent efficacy against human corneal
Mohini Mohan Konai1, Iqbal Pakrudheen, Swagatam Barman
1Antimicrobial Research Laboratory, New Chemistry Unit and School of Advanced Materials, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560064, Karnataka, India. jayanta@jncasr.ac.in.
Abstract:
Cyclam-based antibacterial molecules (CAMs) that display potent activity against both the planktonic and stationary phase of multidrug-resistant Gram-negative bacteria were rationally designed. The optimized compound retained its activity in human plasma and eradicated preformed biofilms. It also revealed excellent potency in an ex vivo model of human corneal infections with negligible propensity of resistance development. This indicated the potential of this class of compound as a future antibacterial agent to tackle human corneal infections.
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