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Extrapolating the Applicability of Measurement Data on Worker Inhalation Exposure to Chemical Substances.

Remy Franken¹, Neeraj Shandilya¹, Hans Marquart²

¹TNO, HE Zeist, The Netherlands.

Annals of Work Exposures and Health

|January 24, 2020

Summary

This study introduces a framework for using existing worker exposure data for new substances or situations. The developed read-across method aids in reliable exposure assessment and regulatory practices.

Keywords:

determinants of exposure exposure assessment for existing substances exposure assessment methodology exposure data evaluation exposure estimation read-across

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Area of Science:

Occupational hygiene
Toxicology
Risk assessment

Background:

Measured exposure data is preferred over modeled estimates in toxicology.
Existing grouping and read-across approaches lack guidance for applying measurement data across different substances and work situations.
A robust framework is needed for leveraging historical exposure data.

Purpose of the Study:

To present a framework for extensive read-across of worker inhalable exposure measurement data.
To enable calculation of read-across factors by evaluating data quality and mapping similarities/differences between substances and work situations.
To provide a basis for regulatory practices in exposure assessment.

Main Methods:

Developed a framework for read-across of existing worker inhalable exposure measurement data.
Incorporated data quality evaluation and similarity/difference mapping.
Based read-across factor calculations on determinants from ECETOC TRA and ART exposure models.
Validated the framework using five case studies.

Main Results:

The framework demonstrated applicability and proof of principle through case studies.
In case studies, the 75th percentiles of measured exposure data fell within the estimated 90% confidence intervals from the read-across approach.
Increased geometric mean of measured exposure correlated with an increase in the geometric mean of estimated exposure.

Conclusions:

The developed framework provides a viable method for read-across of worker exposure data.
Further testing and re-evaluation by experts are recommended for refinement into a widely usable tool.
The framework supports improved exposure assessment and regulatory practices.