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Updated: Dec 30, 2025
Real-Time, Two-Color Stimulated Raman Scattering Imaging of Mouse Brain for Tissue Diagnosis
Published on: February 1, 2022
Surface-enhanced spatially-offset Raman spectroscopy (SESORS) for detection of neurochemicals through the skull at
Amber S Moody1, Taylor D Payne, Brian A Barth
1Department of Chemistry, University of Tennessee Knoxville, Knoxville, TN 37996, USA. bhavya.sharma@utk.edu.
Abstract:
Detection techniques for neurotransmitters that are rapid, label-free, and non-invasive are needed to move towards earlier diagnosis of neurological disease. Surface-enhanced Raman spectroscopy (SERS) allows for sensitive and selective detection of target analytes. The combination of SERS with spatially offset Raman spectroscopy (SORS) in a technique termed surface enhanced spatially offset Raman spectroscopy (SESORS) permits a sensitive and selective detection of neurotransmitters through the skull. Here, we present the SESORS detection of individual neurotransmitters and mixtures of neurotransmitters at physiologically relevant concentrations, while also establishing limits of detection.
